Anti-Tabun gas agent.

[neoprogressivedoraemon]

Hey,friend.
I found something interesting on dtic.mil website.
It's molecular structure of Tabun gas.
It said Tabun is "O-ethyl N,N-dimethyl phosphoamidocyanidate".
Ok,what ever it look like.if I predict correctly.
I mean pronosis.
It will release beta-glocosidase enzyme which very hazardous because it will hydrolyse glycosidase in human body.
And release prussic acid or Hydrogen Cyanide.
How do we treat about this????
So Cyanide playrole is inhibit Cytochrome oxidase in electric transport chain in cellular level especially in brain ,respiratory system,muscular.
I think may be we can make some of competive
I mean cytochrome oxidase mimetic.
Because cyanide inhibit cytochrome oxidase but never do anything about the receptor site in cellular level.
So the body just lack of cytochrome oxidase enzyme.
So we just find another competitive agent of cytochrome oxidase to attach at receptor site when Cyanide inhibit cytochrome oxidase..
This first agent usesage for to be antidote in severe cyanide hazardous.
(Direct from in effective way,I think Intravenous is most quick.)
(But if per os must take a little bit wait for intestinal absorption.)
(But hormone will neutralization because of peptidase in intestinal even use capsular from.)
(But I think we can find something which past digestion and have Cytochrome oxidase mimetic.)
(If somebody know molecular structure of Cytochrome oxidase(active from),please tell me.)
And about detoxification must use another agent.
It's "Sulfur amino acid".
Sound simple,but cyanide sound simple too.
It will detoxification cyanide into "Thiocyanade".
Thio = sulfur .
(I don't know which one of organic-chemical DEA approve.)
But I think we can figure it out,won't we???
So now,the Tabun gas and another cyanide agents can not do anything.
But the best way,I think gas mask ,sound good anyway.:D

[neoprogressivedoraemon]

continue.....
I mean about mammal include human body detoxification cyanide by change cyanide into thiocyanade.
And in this process,the human body will use a lot of sulfur amino acid.
And it conduct severe protein lossing.
So I think give sulfur amino acid with cytochrome oxidase mimetic is good for treatment.:D

[neoprogressivedoraemon]

more details,
If I predict correctly again,Tabun will produce a lot of nitrate too.
More than hydrogen cyanide,(inhibit cytochrome oxidase.)
If ratio of reduction of nitrite into nitrate in human body more than nitrate into ammonia.
(Nitrite->nitrate) : (nitrate->ammonia) > 1
It will conduct severe hypoxia.
Hemoglobin will change into methemoglobin.
And it will distrub oxygen delivering in human body.
And if I can find something more interesting or how do we handle with this,I will tell you more.
(If I wrong please correct me,because Inever experiment this serious agent but analysis from its structure..)
Thank you about reading.

[TerribleTed]

Well, first things first. Tabun (GA) is an organophosphorus nerve agent and has nothing to do with cyanide.

Your chemistry about the cyanide inhibiting cytochrome oxidase c is correct.

Cyanide, as a chemical weapon, is stored in a liquid form and dispersed as a vapor. It is the least toxic of the lethal chemical agents. There are better choices to use, if one has them.

Tabun, and other OP nerve agents, are acetylcholinesterase inhibitors. Therefore, your nerves keeping firing without stopping from the unopposed action of acetylcholine. One typically dies from respiratory distress from the tonically contracted respiratory muscles.


Keep trying!

[neoprogressivedoraemon]

Thank you very much ,TerribleTed ,friend.
About to correct me.:D
And Ted,do you have details of their symtoms or pathogenesis.
I mean everything of victim of Tabun gas.
And organophosphate have antidote????
According to my knowledge,it don't have antidote directly.
But can give muscle relaxant to reduce spasm.
And artificial respiratory in respiratory collape.
But by the way,may be you have more brilliant ideas.
Can we use probiotic to attach at attach site of organophospahate before it attach at receptor site and inhibit acethylcholine esterase.
Or in another hand,make acethylcholine esterase mimetic directly,
How possible it can anti-Tabun???
And thank you very much.

[TerribleTed]

The use of a probiotic is intriguing.

The U.S. has, in the past, used pyridostigmine bromide tablets to bind acetylcholinesterase (AchE) much in the manner of nerve agent. However, it releases AchE in a controlled manner. We use it before we are attacked by nerve agent so as to have a reserve of bound AchE that gets gradually released so we have AchE after the nerve agent has bound the rest. In this manner, one has AchE to cleave acetylcholine and get the muscle/organ to stop contracting.

After one is exposed to nerve agent, we use atropine and pralodoxime. Russia uses a variant of this, basically each country has their own antidote that they like best.

[neoprogressivedoraemon]

Thank you very very much about informations,Ted.:D
I really glad about at least,we have antidotes for protect everybody ,not only soldiers but all people,in America,and another freedom countries all around the world from weapons of mass destruction.:D
And please allow me to ask a few technical questions,please.
About the "pyridostigmine bromide tablets".
In unconventional war or in the sistuations which have high risk about soldiers probably against biological weapons(nerve gas).
About the question ,if soldiers eat 1 of Pyridostigmine bromine tablet.
"How long it can protect soldiers from bio weapons??????"
In my opinions,if doctor give medicine to patient by eat (per os) .
It must take some time before absorb at small intestine into blood circulation system to another organs.
Am I correct????
So another question is..
" How long about if soldiers eat it and it become active????"
Thank you very much.:D